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Prayer is trained by burying bones. Prayers are unlocked as the level in the skill goes up, which are used to aid the player in combat. The prayers can help with Attack, Defence, Strength, Ranged, Magic, and Hitpoints; among other uses. When prayers are activated, they drain the player's Prayer points until the prayer is turned off or all Prayer points are used.

Prayers

Level Effect Drain Rate
1 +5% Defence 1 point per 12 seconds
4 +5% Strength 1 point per 12 seconds
7 +5% Attack 1 point per 12 seconds
8 +5% Ranged 1 point per 12 seconds
9 +5% Magic 1 point per 12 seconds
10 +10% Defence 1 point per 6 seconds
13 +10% Strength 1 point per 6 seconds
16 +10% Attack 1 point per 6 seconds
19 2 x Restore rate for all skills except Hitpoints and Prayer 1 point per 36 seconds
22 2 x Restore rate for Hitpoints 1 point per 18 seconds
25 Player keeps 1 extra item when they die (must be activated before death to occur) 1 point per 18 seconds
26 +10% Ranged 1 point per 6 seconds
27 +10% Magic 1 point per 6 seconds
28 +15% Defence 1 point per 3 seconds
31 +15% Strength 1 point per 3 seconds
34 +15% Attack 1 point per 3 seconds
37 Protects against magic attacks 1 point per 3 seconds
40 Protects against ranged attacks 1 point per 3 seconds
43 Protects against melee attacks 1 point per 3 seconds
44 +15% Ranged 1 point per 3 seconds
45 +15% Magic 1 point per 3 seconds
46 Deals damage up to 25% of your Prayer level to nearby targets upon the user's death 1 point per 12 seconds
49 Heals the player if they fall below 10% health 1 point per 6 seconds
52 Removes 1 Prayer point from an enemy for every 4 damage inflicted on the enemy 1 point per 2 seconds
55 Boosted stats last 50% longer 1 point per 18 seconds
60 +15% Attack +18% Strength +20% Defence 1 point per 1.5 seconds
70 +20% Attack +23% Strength +25% Defence 1 point per 1.5 Seconds
74 +20% Ranged +23% Ranged strength +25% Defence 1 point per 1.5 Seconds
77 +25% Magic +25% Defence 1 point per 1.5 Seconds